| abstract |
A compound of formula (I), wherein: R1 is selected from formulae (II), (III), (IV), (V) and (VI); R2 is a substituted or unsubstituted carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic ring structure. Each optional element is independently a halogen, oxygen, haloalkyl, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl, carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic aryl, amino, nitro, thiol, thioether, imine, cyano, amido, phosphonato, phosphine, carboxyl, thiocarbonyl, sulfonyl, sulfonamide, ketone, aldehyde or ester. The compounds are used in the manufacture of medicaments for the treatment of diseases mediated by the inhibition of CDK4 or CDK4/cyclin complex. |