| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634d7355c2673489b2f4f800541770bb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0356
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-723
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2000-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a456d6c2f0a160c2a65c1140ba4123d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76178b0df838363ca7d7c7d5ad65e1a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d6384b8d8c60758ed2cdc8b26e9e488
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_724e1c382328d859c8b6cca44a914a34 |
| publicationDate |
2003-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-516611-A |
| titleOfInvention |
Mice that are homozygously deficient in CRFR2 and uses thereof in drug screening |
| abstract |
Disclosed are transgenic mice deficient in corticotropin releasing factor receptor 2 (CRFR2). CRFR2 mutant mice are hypersensitive to stress, and display increased anxiety-like behavior. The mice have homozygous defective CRFR2 genes, and exhibit a phenotype of increased anxiety behavior, a hypersensitive hypothalamic-pituitary- adrenal (HPA) axis response to stress and a muted cardiovascular response to urocortin administration. Such knockout mice are useful for screening compounds for anxiety modulating activity, blood pressure control and effect on the response of the hypothalamic-pituitary- adrenal (HPA) axis to stress. |
| priorityDate |
1999-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |