| abstract |
1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines of formula (I) and their salts that are inhibitors of cyclooxygenase-2 activity are disclosed, wherein: X is selected from the group consisting of trihalomethyl, C1-C6 alkyl, and a group of formula (II); wherein R3 and R4 are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6 alkyl; C1-C6 alkoxy; carboxy; C1-C6 trihaloalkyl; and cyano; and Z is selected from the group consisting of substituted and unsubstituted aryl; provided: that when X is either trihalomethyl or C1-C6 alkyl or a group of formula (II) then Z has a different meaning (in terms of substituent groups) corresponding to each of X as defined in the specification. 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines of formula (I) and their salts are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders. |