| abstract |
A compound of formula I, wherein: R1 and R2 are independently selected from -SO2NR72, -C(O)NR72, -NR7SO2R7, -NR7C(O)R7, -SO2OR7, -C(O)OR7, -OSO2R7, or -OC(O)R7, R5 and R6 are independently hydrogen, alkyl, cyano, halo, nitro, -SR8, -C(O)R8, -SO2OR8, -OSO2R8, -SO2NR82, -NR8SO2R8, -OC(O)R8, -C(O)OR8, -C(O)NR82, -NR8C(O)R8, -OR8, or -NR82, Y is independently alkyl, cyano, halo, nitro, -SR, -OR, or -NR2, x is independently 0, 1 or 2, and the linker is a heteroatom-containing chain described herein. The compounds are used in the manufacture of medicaments for the treatment of hyperglycemia, type I diabetes and type II diabetes. |