| abstract |
Compound of the general formula (I) in which A is an acetyl or a 3-(4-fluorophenyl)propionyl group, Xxx1 is D-Nal(1) or D-Nal(2), Xxx2-Xxx3 is D-Cpa-D-Pal(3) or a single bond, Xxx4 is Ser, Xxx5 is N-Me-Tyr, Xxx3 is D-Cit, D-Hci or a D-amino acid group of the general formula (II). Wherein n is the number 3 or 4, where R1 is a group having the general formula (III) where p is an integer from 1 to 4, R2 is an unsubstituted or substituted aryl group or heteroaryl group, or R1 is a 3-amino-1, 2,4-triazole-5-carbonyl group or R1 is a ring of the general formula (IV). In which q is the number 1 or 2, R4 is a hydrogen atom or an alkyl group and X is an oxygen or sulphur atom, Xxx7 is Leu or Nle, Xxx8 is Arg or Lys (iPr), Xxx9 is Pro and Xxx10 is Ala or Sar, or its slat with a pharmaceutically acceptable acid. |