abstract |
A compound or a salt thereof has the formula (VI) wherein g, m, n and p are independently 0 to 2 and the sum of m + n + p = 1 to 4; one of X, Y and Z is C(O), NR6, O, S, S(O), S(O)2 or NS(O)2R7, and the remaining two of X, Y and Z are CR8R9 or CR10R11 or X and Z or Z and Y together constitute a moiety selected from NR6C(O), NR6S(O), NR6S(O)2, NR6S, NR6O, SS, NR6NR6 or OC(O), with the remaining one of X, Y and Z being CR8R9 or n is zero and X, Y and Z together constitute a moiety of formula (II); R20 is NR26R27; R3 is an optionally substituted aryl or heteroaryl radical or R3 is G-A-R-E-Y2; G is an aryl or heteroaryl group; A is -O-, -S-, -NR17-, -CO-N(R17)-, -N(R17)-CO-, -O-CO-, - CO-O-, -O-CO-O-, -HC=CH-, -NH-CO-NH-, -CÂșC, -O-CO-NH-, -NH- CO-O-, -N=N-, -NH-NH-, -CS-N(R18)-, -N (R18)-CS- or a bond; R is alkyl, alkoxyalkyl, aryl, heteroaryl, cycloalkyl, heterocyclo, aralkyl, heteroaralkyl, heterocycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, heterocycloalkoxyalkyl, aryloxyalkyl, heteroaryloxyalkyl, arylthioalkyl, heteroarylthioalkyl, cycloalkylthioalkyl or a heterocycloalkylthioalkyl wherein the heterocyclo is saturated and the aryl or heteroaryl or cycloalkyl or heterocyclo is optionally substituted and R is other than alkyl or alkoxyalkyl when A is -O- or -S-; E is -CO(R19)-, (R19)CO-, -CONH-, -HNCO-, -CO-, -SO2-R19-, - R19-SO2-, -SO2, -NH-SO2- -SO2-NH- or a bond; Y2 is H, alkyl, alkoxy, haloalkyl, aryl, aralkyl, cycloalkyl, heteroaryl, hydroxy, aryloxy, aralkoxy, heteroaryloxy, heteroaralkyl, perfluoroalkoxy, perfluoroalkylthio, trifluoromethylalkyl, alkenyl, saturated heterocyclo, cycloalkyl, trifluoromethyl, alkoxycarbonyl, or aminoalkyl wherein the aryl or heteroaryl or heterocyclo is optionally substituted and R6 to R13, R6', R12', R17 to R19, R26 and R27 are defined in the specification. An intermediate compound has the formula VII wherein D is a nucleophilically displaceable leaving group and m, n, g, R20, X, Y and Z are as defined above. |