| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb66d9373d09efad73c142762f6dfb00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 |
| filingDate |
2000-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e459f46d282e9cd8f0cb99b8e93bdc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca3a69d117e0ead5e0a192ee97a7eac9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88e6dd5a6beb84ae6de571c7bb56b3ca |
| publicationDate |
2001-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-513628-A |
| titleOfInvention |
Method for producing L-phenylephrine hydrochloride |
| abstract |
Process for preparing L-phenylephrine hydrochloride 3 from prochiral N-benzyl-N-methyl-2-amino-m-hydroxyacetophenone hydrochloride 1, the process comprising: (i) Asymmetrically hydrogenating prochiral N-benzyl-N-methyl-2-amino-m-hydroxyacetophenone hydrochloride with [Rh(COD)Cl]2 and a chiral, bidentate phosphine ligand, in a first reaction step. (ii) In a second reaction step, reductively debenzylating the product from step (i) using palladium and hydrogen, to obtain L-phenylephrine hydrochloride 3. Also described is the product prepared by the above process. |
| priorityDate |
1999-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |