| abstract |
Pharmaceutical compositions comprise peptide analogs of high molecular weight kininogen domain 3. The peptides have the formula (a) X1-Asn-Asn-Ala-Thr-Phe-Tyr-Phe-Lys-X2, (b) Cys-Val-Gly-Cys, (c) Thr-Lys-Ile-Cys-Val-Gly-Cys-Pro-Arg-Asp-Ile-Pro-Thr-Asn-Ser-Pro, (d) X5-Leu-Asp-X7-Asn-Ala-Glu-Val-Tyr-X6, or (e) Tyr-Phe-Ile-Asp-Phe-Val-Ala-Arg-Glu-Thr-Thr-X7-Ser-Lys-Glu-Ser wherein: X1, X2, X3, X4, X5, and X6 are from zero to twelve amino acids, independently the same or different, more preferably from zero to six amino acids, and; X7 is Ala or Cys. The peptides are potent inhibitors of angiogenesis and can be used to inhibit endothelial cell proliferation. |