http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-512347-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-723 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-743 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 |
| filingDate | 1999-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e947ae7ed4e28de7687f3019b5d3f43f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1c815e60967aec27f5e7efd2c7cc374 |
| publicationDate | 2003-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-512347-A |
| titleOfInvention | Bioassay for identifying estrogen receptor-alpha/beta selective modulators |
| abstract | A method of screening a test compound that binds to an Estrogen Receptor (ER) in a receptor binding assay by detecting ER-â polypeptide mediated transcription, comprising: a) providing a cell which has an estrogen-regulated DNA sequence encoding MT-II and a DNA sequence encoding ER-â polypeptide, wherein said receptor is transcriptionally active; b) contacting said cell with either the test compound which binds ER or a control; and c) detecting the expression of MT-II, wherein enhanced expression indicates the test compound has estrogen agonist activity, and reduced expression indicates the test compound has estrogen antagonist activity. Also covered is a variation of the above methodology, wherein a method is disclosed to screen test compounds to identify candidates that mimic estrogen's effect on ER-â or ER-á mediated transcription. |
| priorityDate | 1998-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 553.