| abstract |
A multiparticulate tablet which disintegrates in contact with the salvia in the mouth in less than 40 seconds characterised in that it is based on particles of coated active principle which have intrinsic compression characteristics and a mixture of excipients. The ratio of excipient mixture to coated active principle particles being from 04 to 6 parts by weight. The mixture of the excipients comprises: 1. a disintegration agent; 2. a soluble diluent agent with binding properties which consists of polyol having less than 13 carbon atoms. It is the form of either: o a directly compressible product with an average particle diameter of about 100 to 500 micrometers, or o in the form of a powder with an average particle diameter of less than 100 micrometers. In the case where there is only one soluble diluent agent with binding properties, it is used in the form of the directly compressible product. Where there are at least two soluble diluent agents with binding properties, one is present in the directly compressible form and the other is present in the powder form. Where it is possible for the polyols to be the same, the ratio of directly compressible polyol to powder polyol is from 99/1 to 20/80. 3. a lubricant 4. a permeabilising agent, and 5. sweeteners, flavourings and colours. The proportion of disintegration agent being from 1 to 15% by weight and the proportion of soluble agent being from 30 to 90% by weight, based on the weight of the tablet. |