| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D301-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| filingDate |
1999-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8dbbcf641315b9a6bcf2bffe2aae180
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a983e41ff5477816362d707fa0c0fcd1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b08158da629fb0ad9b6d9632c743a62a |
| publicationDate |
2002-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-511452-A |
| titleOfInvention |
Method for the preparation of aryl ethers such as reboxetine |
| abstract |
A method of preparing an amine of formula VIIa by a) oxidizing an optionally substituted trans-cinnamyl alcohol to give and intermediate epoxide of formula Ia; b) reacting the epoxide with an optionally substituted phenol to give a diol of IIa; c) reacting the diol with a silylating reagent to give an alcohol of formula IIIa; d) reacting the alcohol of formula IIIa with reactive derivative of a sulfonic acid to give a compound of formula IVa; e) removing P from the compound of formula IVa to give an alcohol of formula Va; f) displacing the sulfonyloxy group to give and epoxide of formula VIa; g) reacting the epoxide with ammonia to give the compound of formula VIIa. Preparation of intermediate compounds are also described. |
| priorityDate |
1998-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |