http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-509647-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1999-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d036f572742a6b8613b883cded70681 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a8b6bc6d2928aacc3277f84f740ddf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e236dd34a6772020c0568acbc23c65f5 |
| publicationDate | 2003-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-509647-A |
| titleOfInvention | Farnesyl protein transferase inhibitors for treating arthropathies |
| abstract | A farnesyl protein transferase inhibitor of a compound of formula (I), or a compound of formula (II) or (III) which is metabolized in vivo to a compound of formula (I) is used in the manufacture of a medicament for treating arthropathies. The farnesyl protein transferase inhibitor can be in the form of a stereoisomeric form thereof, a pharmaceutically acceptable acid or base addition salt thereof. In formula (I), (II) and (III): the dotted line represents an optional bond; X is oxygen or sulphur; R1 is hydrogen, alkyl, Ar1, Ar2-alkyl, quinolinylalkyl, pyridylalkyl, hydroxyalkyl, alkyloxyalkyl, mono- or di- alkyl aminoalkyl, aminoalkyl, or -Alk1-C(=O)-R9, -Alk1-S(O)- R9 or -Alk1-S(O)2-R9; Alk1 is alkanediyl; R2, R3 and R16 are independently hydrogen, hydroxy, halo, cyano, alkyl, alkyloxy, hydroxyalkyloxy, alkyloxyalkyloxy, aminoalkyloxy, mono- or di-alkyl aminoalkyloxy, Ar1, Ar2- alkyl, Ar2-oxy, Ar2-alkyloxy, hydroxycarbonyl, alkyloxycarbonyl, trihalomethyl, trihalomethoxy, alkenyl, 4,4-dimethyloxazolyl; or when on adjacent positions R2 and R3 taken together may form a bivalent radical of formula -O- CH2-O-, -O-CH2-CH2-O-, -O-CH=CH-, -O-CH2-CH2-, -O-CH2-CH2- CH2-, or -CH=CH-CH=CH-; R4 and R5 independently are hydrogen, halo, Ar1, alkyl, hydroxyalkyl, alkyloxyalkyl, alkyloxy, alkylthio, amino, hydroxycarbonyl, alkyloxycarbonyl, alkyl-S(O)-alkyl or alkyl-S(O)2-alkyl; R6 and R7 independently are hydrogen, halo, cyano, alkyl, alkyloxy, Ar2-oxy, trihalomethyl, alkylthio, di-alkyl amino, or when on adjacent positions R6 and R7 taken together may form a bivalent radical of formula -O-CH2-O- or -CH=CH-CH=CH-; R8 is hydrogen, alkyl, cyano, hydroxycarbonyl, alkyloxycarbonyl, alkylcarbonylalkyl, cyanoalkyl, alkyloxycarbonylalkyl, carboxyalkyl, hydroxyalkyl, aminoalkyl, mono- or di-alkyl-aminoalkyl, imidazolyl, haloalkyl, alkyloxy-alkyl, aminocarbonylalkyl or -O-R10, -S- R10, -N-11R12, R9 to R12 are as defined in the specification; R17 is hydrogen, halo, cyano, alkyl, alkyloxycarbonyl or Ar1; R18 is hydrogen, alkyl, alkyloxy or halo; R19 is hydrogen or alkyl and Ar1 and Ar2 are independently optionally substituted phenyl. |
| priorityDate | 1998-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.