| abstract |
Compounds of formula I, wherein: R1 is H, or optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl, R2 is aryl or heteroaryl, and R3 is H, halo, hydroxy, alkyl, alkoxy, amino, alkylamino, (alkyl)2amino, thio, alkylthio, carboxy, carboxyalkyl, hydroxyalkyl, acyl, aminosulfonyl, alkylaminosulfonyl, (alkyl)2aminosulfonyl. The compounds are used in the manufacture of medicaments suitable for selective inhibition of a PDE4 D isozyme. |