http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-509165-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69108fc12b940ede105638f37f06080b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-19 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 1999-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ff2e498ffd0143cc4014c04900481ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d256a3f3fe5bb3b06d03ef59c19267da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b6ba79b681a0ee41d4920924db7bdeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1fd3be72dae6588f0e1018841b7d3472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_500d2128e7b389d4b9cc770e441f6385 |
| publicationDate | 2003-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-509165-A |
| titleOfInvention | Glycopeptide antobiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same |
| abstract | A glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7 wherein: each dash is a covalent bond A1 comprises a modified or unmodified alpha-amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkanoyl, heterocyclic, heterocyclic-carbonyl, heterocyclic-alkyl, heterocyclic-alkyl-carbonyl, alkylsulfonyl, arylsulfonyl, guanidinyl, carbamoyl, or xanthyl; A2 to A7 comprise a modified or unmodified alpha-amino acid residue, whereby (i) the group A1 is linked to an amino group on the group A2, (ii) each of the groups A2, A4 and A6 bears an aromatic side chain, which aromatic side chains are cross-linked together by two or more covalent bonds, and (iii) the group A7 bears a terminal carboxyl, ester, amide, or N-substituted amide group; wherein one or more of the groups A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues; wherein at least one of said sugar residues is a disaccharide modified to bear one or more substituents of the formula YXR, N+(R1)=CR2R3, N=PRIR2R3, N+R1R2R3 or P+R1R2R3 in which the group Y is a single bond, O, NR1 or S; the group X is O, NR1, S, SO2, C(0)0, C(O)S, C(S)O, C(S)S, C(NR1)O, C(O)NR1, or halo (in which case Y and R are absent); and R, R1, R2, and R3 are independently hydrogen, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkanoyl, heterocyclic, heterocyclic-carbonyl, heterocyclic-alkyl, heterocyclic-alkyl-carbonyl, alkylsulfonyl or arylsulfonyl; and any pharmaceutically acceptable salts thereof; provided that at least one of the substituents of the formula YXR is not hydroxyl; X and Y are not both O ; X and Y are not S and O, or O and S, respectively; and if two or more of said substituents are present, they can be the same or different. Provided that when A4 is linked to a disaccharide having a glucose residue that bears an N-substituted aminohexose residue, then said glucose residue is modified to bear at least one of said substituents YXR, N+(R1)=CR2R3, N=PR1R2R3, N+R1R2R3 or P+R1R2 R3. Also described is a chemical library comprising a plurality of the glycopeptides, a method for preparing the substituted glycopeptides and a glycopeptide antibiotic bearing at least on disaccharide group, said disaccharide group comprising two saccharide groups, a first of said saccharide groups bearing at least one amino or substituted amino group, and a second of said saccharide groups modified to bear at least one substituent which is not hydroxyl, or a pharmaceutically acceptable salt thereof. |
| priorityDate | 1998-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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