http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-508059-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 |
| filingDate | 2000-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d6c58ff73b04f5503f0ade2527a2fac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68841cc961734a100fe3896913cd9062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5af7eef533b8a923683738a121e03d82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b54ba37a4829a95ed43e01d2a167a7a |
| publicationDate | 2002-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-508059-A |
| titleOfInvention | Use of APO B secretion/MTP inhibitors to reduce intestinal fat absorption |
| abstract | A method of reducing intestinal fat absorption in an animal comprises administering an intestinal fat absorption-reducing amount of an apolipoprotein B secretion/microsomal trigyceride transfer protein inhibitor and optionally an antiobesity agent to the animal. A composition containing an apolipoprotein B secretion/microsomal trigyceride transfer protein inhibitor and an antiobesity agent is described. The apolipoprotein B secretion/microsomal trigyceride transfer protein inhibitor (or the stereoisomers and hydrates thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and hydrates) can have the formula (I) wherein L is X-Y-Z or G; X is CH2, CO, CS, or SO2; Y is a direct link, optionally substituted aliphatic hydrocarbylene radicals radical, NH, or O; provided that if X is CH2, Y is a direct link; and Z is hydrogen, halogen, cyano, hydroxy, alkoxy, alkylthio, acyl, thiophenylcarbonyl, alkoxycarbonyl, aryloxy, arylthio, arylalkoxy, arylalkylthio, cycloalkyloxy, cycloalkenyloxy or provided that Y is not O or NH Z is alkylamino, dialkylamino, arylalkylamino, or provided that if X is CH2, Z is H or is unsubstituted vinyl, aryl, cycloalkyl and fused benzo derivatives thereof, polycycloalkyl, cycloalkenyl, polycycloalkenyl or 5 to 14 membered optionally saturated monocyclic or fused polycyclic heterocyclic ring system containing a total of from 1 to 4 ring heteroatoms selected from oxygen, nitrogen, or sulphur and when Z contains one or more rings, the rings may each independently bear 0 to 4 substituents and G is optionally substituted phenyl or 3 to 14 membered optionally saturated monocyclic or fused polycyclic heterocyclic ring system containing a total of from 1 to 4 ring heteroatoms selected from oxygen, nitrogen, or sulphur or G is -CH2-CN, optionally substituted alkyl, perfluoroalkyl, cycloalkyl, cycloalkenyl or -(CH2)n-COR4; can be the compound 9-[4-[4-(2,3-dihydro-1-oxo-1H-isoindol-2-yl)-1-piperidinyl]butyl]-N-propyl-9H-fluorene-9-carboxamide, and the pharmaceutically acceptable salts thereof or the compound 2-[1-(3,3-diphenylpropyl)-4-piperidinyl]-2,3-dihydro-1H-isoindol-1-one or pharmaceutically acceptable salts thereof and the compound 9-[4-(4-[2-(4-trifluoromethylphenyl)benzoylamino]piperidin-1-yl)butyl]-N-2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide and the pharmaceutically acceptable salts thereof. |
| priorityDate | 1999-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.