| abstract |
A sustained-release delayed biodegradable, biocompatible alginate ester hydrogel composition, comprises: a) a biologically active agent such as a protein which can be leptin protein, G-CSF or IL-1ra; b) at least one bound polyvalent metal ion and c) a biodegradable anionic polysaccharide which is an alginate ester crosslinked with the polyvalent metal ion. The gel composition is formed in a time-delayed manner, is injectable, and results in no injection site reaction. The gel composition is useful for treating diabetes, high blood lipid levels, arterial sclerosis, arterial plaque, obesity or stroke or the prevention or reduction of gall stones formation, |