| abstract |
A sulphonamide derivative of formula (I) or a pharmacologically acceptable salt, ester or amide derivative thereof are useful in preventing or treating arthritis or for inhibiting metastasis, invasion or growth of cancer wherein: R1 is hydroxy or hydroxyamino; R2 is hydrogen, optionally substituted alkyl, cycloalkyl or -A-R6 A is alkylene or alkylene interrupted by an oxygen atom, -S(O)m- or -N(R9)-; R6 has the formula (II), (III) or (IV); X is oxygen, a sulphur, -N(R10)- or -C(R11)(R12)-; Y is oxygen, carbonyl, -S(O)n-, -N(R10)- or -C(R11)(R12)-; R7 and R8 are independently hydrogen, carboxyl, halogen, cycloalkyl, haloalkoxy, alkanoyl, haloalkylthio, amino, mono-alkylamino, di-alkylamino, cyano, nitro, optionally substituted aryl, heteroaryl, aryloxy, heteroaryloxy, arylthio, heteroarylthio or an optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl or alkylsulphonyl, or R7 and R8 may form, together with the carbon atoms to which they are attached, a substituted non-aromatic hydrocarbon ring, a non-aromatic heterocycle, a non-aromatic hydrocarbon ring or a non-aromatic heterocycle, an optionally substituted aryl ring or a heteroaryl ring. with the proviso that when R7 and R8 are attached to the same carbon atom, R7 and R8 do not form, together with the carbon atom to which they are attached, an optionally substituted aryl ring, a heteroaryl ring; m and n are independently 0, 1 or 2; R9 to R12 are as defined in the specification; R3 is hydrogen atom, optionally substituted alkyl, cycloalkyl, alkenyl or alkynyl; R4 is optionally substituted arylene or heteroarylene; R5 is optionally substituted alkyl, aryl or heteroaryl; with the proviso that when R2 is hydrogen, optionally substituted alkyl or a cycloalkyl, R3 is an optionally substituted alkynyl. |