| abstract |
Estratriene intermediate compounds of formula (I) where: X is halogen, -NHMe, OH or a protected hydroxy group A is a ring of formula (II); R3 is H or -OR3 is a protected hydroxy group; R14, R15a, R15b, R16a and R16b are each H or R14 and R15a are a bond or a CH2 bridge or R15b is Me and R15a is H or R15a and R15b are Me or R15b and R16b is a CH2 bridge or R16a or R16b are halogen or R16a+R16b is methylidene and the remaining substituents from R14, R15a, R15b, R16a and R16b are each H; R17' in a or b position is H; R17'' is H or COR17"; R17''' is H or hydrocarbon radical with up to 8 carbon atoms or R17' and R17'' together are O. |