http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-506787-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-70 |
| filingDate | 1999-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39c877cd5f3e3d1693817ca5555b717a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ea1b420cb8f38ead140ed465124a0bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23da23cc5f6b0fd065a1d7704b76836d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c993519c4cc61aaa2920228e533f50eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7757ef2d4bf123ae90dbdd758418436c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db1c30ca5d5a6229c66afccb1eb5c16e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1b13c52d5d2891347c9170eaf8f9d55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_733dda56f04f396e6ac5918f30573d98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_365d6c008ac0e8dce16ca0477eba79ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd353bc9b009350567061c9d0ce4b4a2 |
| publicationDate | 2003-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-506787-A |
| titleOfInvention | Trisubstituted 1,3,5-triazine derivatives having HIV replication inhibiting properties for treatment of HIV infections and preparation process thereof |
| abstract | The use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, for the manufacture of a medicine for the treatment of HIV (Human Immunodeficiency Virus) infection, wherein: A is CH, CR4 or N; n is 0,1,2,3 or 4; R1 and R2 are hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono-or di (C1-12alkyl)amino, mono-or di (C1-12alkyl) aminocarbonyl wherein each of the aforementioned C1-12alkyl groups may optionally and each individually be substituted with one or two substituents each independently selected from hydroxy, C1-6alkyloxy, hydroxy C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, cyano, amino, imino, aminocarbonyl, aminocarbonylamino, mono-or di (C1-6alkyl)amino, aryl and Het; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono-or di (C1-12alkyl) aminoC1-4alkylidene; R3 is hydrogen, aryl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and each R4 independently is hydroxy, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy ; L is-X-R5 or-X-Alk-R6; wherein R5 and R6 each independently are indanyl, indolyl or phenyl; each of said indanyl, indolyl or phenyl may be substituted with one, two, three, four or five substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, hydroxy, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, formyl, cyano, nitro, amino and trifluoromethyl; Alk is C1-4alkylene; and X is-NR3-,-NH-NH-,-N=N-,-O-,-S-,-S (=O)-or-S (=O) 2-; aryl is phenyl or phenyl substituted with one, two, three, four or five substituents each independently selected from halo, C1-6alkyl, C1-6alkyloxy, cyano, nitro and trifluoromethyl; Het is an aliphatic or aromatic heterocyclic radical; said aliphatic heterocyclic radical is selected from pyrrolidinyl, piperidinyl, homopiperidinyl, piperazinyl, morpholinyl, tetrahydrofuranyl and tetrahydrothienyl wherein each of said aliphatic heterocyclic radical may optionally be substituted with an oxo group; and said aromatic heterocyclic radical is selected from pyrrolyl, furanyl, thienyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl wherein each of said aromatic heterocyclic radical may optionally be substituted with hydroxy. |
| priorityDate | 1998-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.