| abstract |
A tumor necrosis factor-a converting enzyme (TACE) is produced, purified, and crystallized is disclosed. The three-dimensional coordinates of the crystal are obtained by X-ray diffraction. The coordinates can be recorded on a computer readable medium, or are part of a video memory, where they can be used as part of a system for studying TACE. The coordinates are also used in designing, screening, and developing compounds that associate with TACE. |