| abstract |
Antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. Phenoxyalkylamine derivatives of the formula (1) where R1 and R2, independently, are hydrogen, halogen, or a C1-4 alkyl group; R3, R4, and R5, independently, are hydrogen or C1-4 alkyl group; R6 represents hydrogen, C1-4 alkyl, or a benzyl group; R7 means nitro group or amino group optionally monosubstituted by C1-4 alkyl, benzoyl, C1-4 alkylcarbonyl, C1-4 alkylsulfonyl, C1-4 alkylcarbamoyl or a C1-4 alkylthiocarbamoyl group; both n and m are 0 or 1, providing that R2 is different from hydrogen when R1 is hydrogen. Also described are stereoisomers or mixtures of stereoisomers, acid addition salts, hydrates, prodrugs, and metabolites of all these compounds. |