| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27155ed29f9b0bfa281f4b21b26d709a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
1998-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dc3e6490e2acdf3c0462e3f8abb3a56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5bae8f8afe17c19c54f2b26b2043b1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f79156032582fe558a030ccb430b1fb8 |
| publicationDate |
2003-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-504570-A |
| titleOfInvention |
Site-specific preparation of hGRF-PEG with PEG units covalently bound to Lys12, Lys21 or amino terminal |
| abstract |
A method is described for the site-specific preparation of hGRF-PEG conjugates containing one or more PEG units (per hGRF) covalently bound to Lys12 and/or Lys21 and/or Ná, comprising carrying out a pegylation reaction between the hGRF peptide and the activated PEG in solution at a pH between 7 and 9 and thereafter isolating and purifying the desired hGRF-PEG from the reaction mixture by chromatography. The conjugates prepared by this method, as well as their use in the treatment and/or diagnosis of growth hormone deficiency, are also described. |
| priorityDate |
1997-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |