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filingDate 1998-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2002-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NZ-504405-A
titleOfInvention Method for killing bacteria or fungi comprising contacting them mammalian haemoglobin proteins and fragments thereof
abstract Compositions are provided, which are useful as antimicrobial agents. The compositions comprise mammalian haemoglobin, the alpha and beta chains of haemoglobin free of haeme, fragments of the alpha and beta chains that result from cyanogen bromide cleavage of the alpha and beta chains, and synthetic peptides derived therefrom. The compositions exert antimicrobial activity against both bacteria and fungi that is comparable to known antimicrobial peptides from human neutrophils, cathepsin G and azurocidin. Sensitive organisms include Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, Gram-positive bacteria such as Staphylococcus aureus and Streptococcus faecalis, and the fungus Candida albicans. Methods for preparing the compositions also are provided. Additionally, the compounds described can be used as disinfectant agents to sterilize or maintain microbe-free products. Such products can include baby wipes, diapers, bandages, towelettes, make-up products, eyewash and contact lens solutions. They may be administered to such products topically, in appropriate buffer or in liposome compositions. The antimicrobially effective amount to be administered will typically be in the range of from about 1500 ug to 50 mg/kg of treated material.
priorityDate 1997-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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