| abstract |
The imidazole derivative, or a pharmaceutically acceptable salt or isomer thereof, where the imidazole derivative is represented by the formula (1): wherein: n1 is 1 to 4, A is H; alkyl which may be optionally substituted by cycloalkyl or lower alkoxy; or a radical selected from a group depicted by (2): wherein R1 and R1' independently of one another represent H, halogen, cyano, nitro, hydroxycarbonyl, aminocarbonyl, aminothiocarbonyl, lower alkoxy, phenoxy, phenyl, benzyloxy, or lower alkyl which may be optionally substituted by cycloalkyl; R2 represents H or lower alkyl, or represents -E-F wherein E is -CH2-, -C(O)- or -S(O)2- and F is H; lower alkyl which may be optionally substituted by phenoxy or biphenyl; lower alkoxy which may be optionally substituted by aryl; phenyl; benzyl; benzyloxy; or amino which may be optionally substituted by lower alkyl, benzyl or cycloalkyl, R3 represents H, lower alkyl or phenyl, R4 represents a radical selected from a group depicted by 3: Y represents a radical selected from a group depicted by 4: wherein X represents O or S, B represents H, or lower alkyl which may be optionally substituted by hydroxy, mercapto, lower alkoxy, lower alkylthio or aryl, C represents H, or lower alkyl which may be optionally substituted by aryl; or represents a radical selected from a group depicted by 5. A process for preparing the imidazole derivative of formula (1) and the intermediates used in the preparation of the imidazole derivative of formula (1) are also described. Pharmaceutical compositions comprising the imidazole derivative of formula (1) are useful for preventing and treating cancer, restenosis, atheroschlerosis; or for preventing or treating infections from hepatitis delta and related viruses. |