| abstract |
A 2-aminotetraline has the formula (I) and its pharmaceutically acceptable salt has the formula (II) wherein: X- is the monovalent anion of a pharmacologically acceptable acid; R and R1 is halogen, hydroxy, alkoxy optionally substituted in the position w with OH or NR3R4, or alkanoyl, alkyl, carbamoyl, carbamoyloxy or NR3R4; R2 is hydrogen; halogen, hydroxy or methoxy and R3 and R4 are independently H or alkyl optionally substituted in position w with groups OH or NH2 limited by the provisos listed in the specification. A pharmaceutical composition thereof is useful for treating rheumatoid arthritis, pancreatitis, inflammatory bowel disease, systemic lupus erythematosus, glomerulonephritis and encephalomyelitis. |