| abstract |
A compound of formula (I), wherein: A is CH2 or O; R1 is H, halo or alkyl; R2 is H, alkyl or CH2NR"R"; X is O or CH2; Y is of the formula (II), (III), (IV), (V), (VI), (VII) or (VIII); wherein G is NR", S or O; R' is H, alkyl, -Oalkyl, -Salkyl, NR"R" or halo; each R" independently is H or alkyl; and s is 0, 1 or 2. Pharmaceutical compositions comprising the compounds of formula (I) are also described. The compounds of formula are useful for the treatment of disease in which antagonism of the anb3 receptor or the anb5 receptor is indicated. |