| abstract |
A 1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivative of the formula I or pharmaceutically suitable acid addition salts thereof useful as AMPA/Kainate receptor inhibitors wherein: A is a hydrogen atom; B is a hydrogen atom; R1 is a group of the formula -(CH2)n-CO-(CH2)m-R; R is a halo atom, a pyridyl group or -NR3R4; R3, R4, R7 and R8 are as defined in the specification; n is 0, 1 or 2; m is 0, 1 or 2, or A forms together with B a valence bond between the carbon atoms in positions 8 and 9, and in this case R1 is a group of the formula -CO-(CH2)-R6; R6 is a halo atom, a phenoxy group, an alkoxy group or a group of the formula -NR7R8, p is 0, 1 or 2, R2 stands for a nitro group, an amino group or an alkanoyl-amino group, and limited by the proviso defined in the specification. |