| abstract |
A composition for treating rapid onset of affective actions contains a first component being a 5-HT reuptake inhibitor and a second component being a h5-HT1B antagonist or partial agonist. The second component has the formula (I) wherein: X is CH2 or O; Y is CONH or NHCO; R1 is H, alkyl or cycloalkyl; R2 is H, alkyl, alkoxy or halogen; R3 is morpholino, -C(O)-morpholino, 4-oxo-piperidino or C(O)NR4R5; R4 and R5 are independently H or alkyl. The second component can be in the form of a R- or S- enantiomer, a racemate, the free base, solvate or pharmaceutically acceptable salts thereof and the first component can be in the form of the free base, solvates or pharmaceutically acceptable salts thereof. |