| abstract |
Compounds of general formula (I) wherein: R is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl R1 is hydrogen or halogen, or R and R1 may be together -CH=CH-CH=CH- R2 and R2' are independently hydrogen, halogen, trifluoromethyl, lower alkoxy or cyano, or R2 and R2' may be together -CH=CH-CH=CH-, optionally substituted by one or two substituents selected from lower alkyl or lower alkoxy R3 is hydrogen, lower alkyl, or form a cycloalkyl group R4 is hydrogen, -N(R5)2, -N(R5)(CH2)nOH, -N(R5)S(O)2-lower alkyl, -N(R5)S(O)2-phenyl, -N=CH-N(R5)2, -N(R5)C(O)R5 or a cyclic tertiary amine X is -C(O)N(R5)-, -(CH2)mO-, -(CH2)mN(R5)-, -N(R5)C(O)- or -N(R5)(CH2)m- n is 0-4 m is 1 or 2 Also disclosed is a process for preparing compounds of formula I and the use of the compound in treating diseases related to NK-1 receptor antagonists. |