| abstract |
Described are compounds of formula (I), wherein One of X and X' is hydrogen, halogen, or C1-6 alkyl, the other is a group of formula (II), or one of X and X' is a group of formula (III), wherein Het is a 5- or 6-membered heteroaromatic ring or Het is a 9- or 10-membered bicyclic heteroaromatic ring, or one of X and X' is a group of formula (IV), and Y is a group of formula (V), or a group selected from a 5- or 6-membered monocyclic heteroaromatic group containing 1-3 heteroatoms selected from N, O, and S or a 10-membered bicyclic heteroaromatic group containing 1-4 heteroatoms, selected from N, O, and S, wherein the heteroaromatic group is bonded via a carbon atom to the amide carbonyl, and Z is hydrogen or C1-6 alkyl. The compounds are used as medicaments for treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and asthma. |