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filingDate 1998-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2003-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NZ-502670-A
titleOfInvention Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
abstract A process for the preparation of benzothiazine dioxides of formula (I), which act as potent endothelin A antagonists with profound in vitro activity. The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid haemorrhage.
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