| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7dfd84f9157ae12c41e319ec325338d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 |
| filingDate |
1998-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b14c7f70300bf1af941e036ae6af248
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7520b4324c4b711164daf24ed4838b6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_071438774441774905e5de55196244f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8237a615bdf2e6ccf5e1248b745ac518
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b4c6240818cfd4ba651dcf12d52bdb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cdac47f3bdaf0555a9a6db0972a2233 |
| publicationDate |
2001-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NZ-502234-A |
| titleOfInvention |
Process for the selective preparation of z-isomers of 3-(2-substituted vinyl) cephalosporins |
| abstract |
A process for the selective production of the Z-isomer of a 7-N-unsubstituted or substituted -amino-3-[2-(4-substituted or unsubstituted-thiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid or ester thereof represented by the general formula (IV): wherein R1 denotes a hydrogen atom, a mono-valent amino-protecting group or a 2-(2-N-protected or unprotected-aminothiazol-4-yl)-2-alkoxyiminoacetyl, R2 denotes a hydrogen, or R1 and R2 as taken together mean one divalent amino-protecting group, R3 is hydrogen, pivaloyloxymnethyl group or a carboxyl-protecting group and R8 denotes an alkyl or the like. The above compounds can be prepared at high selectivities and in high yields by reacting a compound of general formula (I): wherein R1, R2 and R3 are each as defined above; and R4 denotes a lower alkyl group or an aryl group with a 4-substituted or -unsubstituted thiazole-5-carbaldehyde in a mixed solvent comprising a chlorinated hydrocarbon and a lower alkanol at a temperature of as low as +5 °C or below. The compounds produced can be used as cephalosporin antibiotics. |
| priorityDate |
1997-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |