| abstract |
The compound has the formula (I), wherein: A is an aromatic of formula (II) or (III): R1 and R2 are independently H, halogen, OH, alkyl or alkoxy; R3 is H, alkyl or a -COR4 radical (R4 is alkyl); B is alkyl, phenyl, pyridinyl or a heterocycle with 5 members containing from 1 to 4 heteroatoms chosen from O, S, N, where the carbon atoms are optionally substituted by one or more groups chosen from alkyl, alkoxy and halogen; X is -CO-N(R3)-X'-, -NH-CO-X'-, -CH=, -CO- or a bond (X' is -(CH2)n, with n an integer from 0 to 6); Y is -Y'-, -CO-NH-Y', Y'-NH-CO-, -CO-Y'-, Y'-CO-, -N(R3)-Y'-, Y'-N(R3)-, Y'-CH2-N(R3)-CO-, -O-Y'-, -Y'-O-, -S-Y'-, -Y'-S-, -Y'-O-Y'-, -Y'-N(R3)-Y'- or a bond (-Y is -(CH2)n, with n an integer from 0 to 6); Het is a heterocycle containing from 1 to 5 heteroatoms chosen from O, N, S which can be substituted by one or more substituents X'-OR3, X'-NR3, X'-S-R3. Pharmaceutical preparations comprising the compound of formula (I) are also described. The compounds of formula (I) are used to inhibit NO synthase and/or to inhibit lipidic peroxidation. |