| abstract |
Described are compounds of the formula: in which Ar is a 3,4-disubstituted phenyl where each substituent is selected independently of the other from the group consisting of nitro, cyano, trifluoromethyl, carboethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, and halo; Z is NHR1 where R1 is H or alkyl of 1 to 10 carbon atoms; and Y is (i) a phenyl, unsubstituted or substituted with one or more substituents each selected, independently one from the other, from the group consisting of nitro, cyano, trifluoromethyl, carboethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, and halo, or (ii) naphthyl. Typical compounds include: 3-(N-benzoylamino)-3-(3,4-dimethoxyphenyl)propionamide, 3-(N-benzoylamino)-3-(3,4-diethoxyphenyl)propionamide, 3-(N-benzoylamino)-3-(3,4-diethylphenyl)propionamide, 3-(N-benzoylamino)-3-cyclohexylpropionamide, 3-[N-(3-aminobenzoyl)amino]-3-(3,4-diethoxyphenyl)propionamide, 3-[N-(3-methoxybenzoyl)amino]-3-(3,4-diethoxyphenyl)propionamide, 3-[N-(4-methoxybenzoyl)amino]-3-(3,4-diethoxyphenyl)propionamide, methyl 3-(N-benzoylamino)-3-(3,4-diethoxyphenyl)propionate, methyl 3-[N-(3-aminobenzoyl)amino]-3-(3,4-diethoxyphenyl)propionate, methyl 3-[N-(3-methoxybenzoyl)amino]-3-(3,4-diethoxyphenyl)propionate, methyl 3-[N-(4-methoxybenzoyl)amino]-3-(3,4-diethoxyphenyl)propionate, methyl 3-(N-benzoylamino)-3-(4-trifluoromethylphenyl)propionate, methyl 3-(N-benzoylamino)-3-(4-acetylphenyl) propionate. |