http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-501415-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-18 |
| filingDate | 1998-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4ec6647fbe2b152daf0b0ff9adbddcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67281977e2a689489486099ee9ba14aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec74e34ffd9b43091ad577e6d6f0ab82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed79188d0f9a9bb04d308dc11443db2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a1bf6c9fb7e60117f80efbb358b10f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_143c32ac22bc77c9ce01d2ef1cb18a7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09c05d4af69544eb152aa11b62f5dcfb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63851113e52fa453f615713bcb3577fe |
| publicationDate | 2001-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-501415-A |
| titleOfInvention | Benzimidazole derivatives (optionally with saccharide substituents) useful for the treatment or prophylaxis of viral infections (particularly herpes, cytomegalovirus and Hepatitis B) or for the treatment or prophylaxis of restenosis |
| abstract | The benzimidazole derivative of formula (I) or salt or pharmaceutical composition thereof, where in the formula (I): R1 is halogen, hydroxy, azido, alkyl, alkoxy, alkenyl, alkynyl, arylalkenyl, arylalkynyl, or -NR19R20 (where R19 and R20 may be the same or different and are H, alkyl, cyanoalkyl, hydroxyalkyl, haloalkyl, cycloalkyl, alkylcycloalkyl, alkenyl, cycloalkylalkyl, alkynyl, aryl, arylalkyl, heterocyclealkyl, alkylcarbonyl, arylsulfonyl, or R19R20 together with the N atom to which they are attached from a 3, 4, 5 or 6 membered heterocyclic ring), OR21 (where R21 is H, alkyl, cycloalkyl, or aryl), or SR22 (where R22 is H, alkyl, hydroxyalkyl, cycloalkyl, or aryl). R2 is H or halogen. R3 and R4 may be the same or different and are H, halogen, alkyl, aryl, heterocyclearyl, alkoxy, haloalkyl or -SR24 (where R24 is H, alkyl, aryl, or arylalkyl). Z is a substituent of formula (la) or (Ib), wherein: R5 is H, alkyl, haloalkyl or alkoxy. R6 is H, hydroxy, halogen, alkyl, hydroxyalkyl, haloalkyl or alkoxy. R7 is H, hydroxy, halogen, alkyl, hydroxyalkyl, haloalkyl, alkoxy, or R6 and R7 together form a ketone or alkene. R8 - R11 may be the same or different and are H, hydroxy, halogen, alkyl, hydroxyalkyl, haloalkyl, alkoxy, or any of R8 and R9 or R10 and R11 together form a ketone or alkene. R12 - R14 may be the same or different and are H, hydroxy, alkyl or hydroxyalkyl. With the following provisos: i) The compound of formula (I) cannot be 2,5-dimethyl-1-(2,3,4-tri-O-acetyl-beta-D-xylopyranosyl)-1 H-benzimidazole or 5,6-dimethyl-1-(2,3,4-tri-O-acetyl-beta-D-arabinopyranosyl)-benzimidazole-2-thione. ii) When Z is a substituent of formula (la) R2, R3, and R4 cannot all be H. iii) When Z is a substituent of formula (la) or (Ib) R1 cannot be NR19R20 where R19 and R20 together with the N atom to which they are attached form a 5 membered heterocyclic ring containing S. The compound or salt of formula (I) is used for the treatment or prophylaxis of a viral infection (especially herpes, cytomegalovirus and Hepatitis B) or for the treatment or prophylaxis of restenosis. |
| priorityDate | 1997-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 491.