http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-501376-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb9db3864b115c793e9c73626666c8bb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 |
| filingDate | 1998-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_797bded9c9e3f1110a5e6292ef9aff50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d514b1ffb034fdad7bf968e0d11bc36b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c89360f1e8b4d0ae75a0d278f5f72c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16eaa9c832d1415fdaa63d453f9408a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1270e2429e734c8283cb38913faf210 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f69c34ee77e52a3de83cc8d3e8b4d1f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1c133cb5c4160d0d4e632b5166ce4df |
| publicationDate | 2002-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-501376-A |
| titleOfInvention | 4-(6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-yl)-2-piperazine-carboxamide derivatives useful for inhibition of farnesyl protein transferase |
| abstract | A 4-(6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-yl)-2-pipera zine-carboxamide derivative or a pharmaceutically acceptable salt or solvate thereof has the formula (1.0) wherein: a is N or NO-; Ra, Rb, Re and Rd are independently halo, alkyl or alkoxy provided that at least one, but not more than two of Ra, Rb, Re and Rd are H; the dotted line (---) is an optional double bond; R is H, -C(O)-CH2-O-(CH2)2-O-CH3, -S(O)2R1, -S(O)2NR1R2, -C(O)R1 or -C(O)NR1R2; R1 and R2 are independently H, optionally substituted alkyl, aryl, arylalkyl, triazolyl, 2-, 3- or 4-pyridyl or pyridyl N-oxide, heteroarylalkyl, cycloalkyl, cycloalkylalkyl or heterocycloalkyl; Re and Rf are independently H or optionally substituted alkyl, alkyloxyalkyl, aryl, arylalkyl, triazolyl, alkyloxyalkyloxyalkyl, 2-, 3- or 4-pyridyl or pyridyl N-oxide, imidazole, cycloalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkyl or Re is H, alkyl or aryl and Rf is -(CH2)n-R15 or Re and Rf together with the nitrogen to which they are bound form an optionally substituted piperidine or pyrrolidine; n is 0 to 8; R15 is C(O)NH2, -SO2NH2, benzodioxoxlyl or optionally substituted aryl, heteroaryl, cycloalkyl or heterocycloalkyl or R15 is -C(A)-B NR16R17; B is OH or NH2; A is NH, O, NOH or NCN; R16 is H or alkyl; R17 is H, alkyl, SO2CH3 or C(O)NH2 and Rh is H or =O; provided that when Rh is H and Rb and Rd are both H then Re is H and Rf is a group of formula (2) and heteroaryl alone or as part of heteroarylalkyl is a 5 or 6 membered heterocyclic having at least one heteroatom N, S or O. A pharmaceutical composition thereof is useful for inhibiting the abnormal growth of cells such as tumor cells expressing an activated ras oncogene specifically pancreatic tumor cells, lung cancer cells, myeloid leukemia tumor cells, thyroid follicular tumor cells, myelodysplastic tumor cells, epidermal carcinoma tumor cells, bladder carcinoma tumor cells, or colon tumor cells. |
| priorityDate | 1997-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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