abstract |
The hydrochloride or fumarate of 1-{2-[(2R)-(3,4-dichlorophenyl)-4-(3,4,5-trimethoxybenzoyl)morpholin-2yl]ethyl}spiro[benzo(c)thiophene-1(3H), 4'-piperidin]-(2S)-oxide. The compounds act to inhibit NK1 or NK2 receptors and are useful in treating tachykinin-mediated diseases, asthma, bronchitis, rhinitis, urinary incontinence and ulcerative colitis. |