| abstract |
Branched, substantially non-antigenic polymers designated as (R)n-L-COOH are disclosed. L is depicted above. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologically active material are used as attachment sites. Methods of forming the polymer, conjugating the polymers with biologically active moieties and methods of using the conjugates are also disclosed. |