| abstract |
Compounds of formula (I) wherein, R1 and R2 are independently selected from hydrogen and loweralkyl; R3 is selected from alkenyl, alkyl, alkynyl, aryl, arylalkyl and heterocycle; and R4 is selected from aryl and heterocycle; wherein each of the foregoing aryl, heterocycle, and aryl part of the arylalkyl is unsubstituted or substituted with one, two, or three substituents independently selected from the group consisting of F, Cl, Br, I, cyano, carboxamido, hydroxy, loweralkoxy, loweralkyl, loweralkenyl, loweralkynyl, amino, loweralkylamino, di(loweralkyl)amino, N-loweralkyl-N-loweralkoxyamino, trifluoromethyl, and methoxymethyl. The compounds act to inhibit adenosine kinase and are useful in treating ischemia, neurological disorders, nociperception, inflammation, immunosuppression, gastrointestinal disfunctions, diabetes and sepsis. |