| abstract |
rocess for the preparation of O-sulfated K4, K5 and K40 polysaccharides useful for the treatment of tumoral, HIV-1 and coagulation pathologies and in cosmetic preparations, wherein the K4, K5 or K40 polysaccharide in the form of sodium salt is suspended in an aprotic solvent and directly submitted to the reaction of O-sulfation with a pyridine-sulphur trioxide or trimethylamine-sulphur trioxide adduct or with chlorosulfonic acid. Also included is the use of said O-sulfated polysaccharides in the treatment of tumoral, HIV-1 and coagulation pathologies, cosmetic compositions and in the prevention of hair loss. |