http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-337195-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aac141a3051e128a54ab3843e7aa47e2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate | 1998-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02edfdfb54d249a1c4f929fcc1739498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60b8bef6d4682803b697e2f1e42a98a2 |
| publicationDate | 2001-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-337195-A |
| titleOfInvention | Epothilones with a modified side chain |
| abstract | Process for the preparation of epothilones that are modified in the side chain, wherein: 1. for the preparation of epothilones which are modified in the 16, 17-position the starting materials are 3,7-protected or unprotected epothilones A or B and a. hydrogenation on the 16, 17-double bond or b. an addition reaction with halogen on the 16,17 double bond or c. epoxidation on the 16,17-double bond and, if appropriate, the resulting epoxide is reduced to give the 16-alcohol; or 2. for the preparation of 2,3-unsaturated epothilone N oxides either a. 3,7-protected epothilones A or B are converted into an N oxide in a manner known per se and, the 3-substituent is eliminated by a base to give the 2,3-double bond, or b. 7-protected or 7-unprotected epothilones A or B which have a double bond in the 2,3-position are converted into an N-oxide in a manner known per se; or 3. for the preparation of epothilone N-oxides 3,7protected or unprotected epothilones A or B are converted into an N-oxide in a manner known per se; or 4. for the preparation of epothilones which are modified in the C19-position 3,7-protected or unprotected epothilones A or B are metalated in the C19-position and captured with electrophilic reagents in a manner known per se as alkyl-, aryl-, heteroaryl-, halogen-, oxygen- or sulphur-substituted epothilones which are modified in the C19-position; or 5. for the preparation of epothilones that are modified in the C27-position the allyl group (C17, C16 and C27) is substituted in a manner known per se on the C27-methyl group by a hetero atom. N-oxide epothilones of formulae (I) and (II) can be made by this method, wherein for formula (I), R, R1 and R2 are hydrogen, Z is O- and for formula (II), R1 and R2 are hydrogen, Z is O- and R is methyl. |
| priorityDate | 1997-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.