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filingDate 1998-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NZ-336793-A
titleOfInvention Method for stabilizing peptides by adding an organic acid and then lyophilizing the peptide mixture
abstract The method of stabilizing a peptide containing the sequence -Asp-Gly or -Asn-Gly which sequence may be susceptible to conversion into a succinimide moiety of formula 1 or a b-rearranged moiety of formula 2 comprises: a) providing a solution of a peptide, b) adding an organic acid and adjusting the pH of the solution to 5 to 6.5 and c) lyophilizing the resulting mixture.. The organic acid can be tartaric acid, citric acid or acetic acid and the peptide can be a hirudin variant or desulphatohirudin. Saccharose and mannitol can also be added to the solution.
priorityDate 1997-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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