| abstract |
Heptapeptide analogues or pharmaceutically acceptable salts thereof, with oxytocin antagonist activity, consist of a hexapeptide moiety S and a C-terminal 'beta'-aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the 'beta'-aminoalcohol Z is -NR-CH(Q)-CH2OH, Q is (CH2)n-NH-A, n is 1-6 and A is H or -C(=NH)NH2, and R is CH3 or C2H5. The moiety S is Mpa-X-Ile-Y-Asn-Abu wherein Mpa is 3-mercaptopropionis acid, X is a D-aromatic alpha-amino acid, Y is an aliphatic alpha-amino acid and Abu is alpha-aminobutyric acid. The peptides are useful in the control of uterine contractions. |