| abstract |
Provided a compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof. Formula (I) includes an asymmetric centre in the amino acid group, and although the natural L or (S) configuration of arginine is preferred, it is intended that formula (I) includes both (S) and (R) enantiomers either in substantially pure form or admixed in any proportions. Specifically described are: (R/S)-[2-(1 -iminoethylamino)ethyl]-DL-homocysteine (S)-[2-(1-iminoethylamino) ethyl]-L-homocysteine; and (R)-[2-(1 -iminoethylamino)ethyl]-D-homocysteine and salts, solvates, and physiologically functional derivatives thereof. Salts and solvates of compounds of formula (I) which are suitable for use in treating clinical conditions such as arthritis, asthma, ileus and migraine are those wherein the counterion or associated solvent is pharmaceutically acceptable. S Salts and solvates having non-pharmaceutically acceptable counterions or associated solvents are useful as intermediates in the preparation of other compounds of formula (I) and their pharmaceutically acceptable salts, solvates, and physiologically functional derivatives. |