| abstract |
The 3-nitro-imidazo[1,2-b]pyridazines or salts or N-oxides thereof have the formula I wherein: R1 is H, optionally substituted alkyl, alkylcarbonyl, alkoxycarbonyl, sulpho (-SO3), or an optionally substituted pyrazolyl, furan, thiophene, imidazole, imidazoline, oxazole, isoxazole, thiazole, thiazoline, isothiazole, triazole, oxadiazole, thiadiazole, thiadiazole-1-oxide, tetrazole, hexanopyranose, benzene, pyridine, pyridine-N-oxide, pyridazine, pyrimidine, pyrazine, triazine, naphthalene, quinoline, quinazoline, quinoxaline, benzimidazole, benzoxazole, benzothiazole, thiazolopyridine or imidazolopyridine; R2 is H, alkyl or halogen; A is alkylene; X is absent, oxygen or sulphur; Y is oxygen, sulphur or N-alkyl and Z is oxygen or sulphur. A medicament thereof is used for the control of helicobacter bacteria. |