http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-335598-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-06 |
| filingDate | 1997-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e7a8633e7543c80ec8dce655915fd3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4b2663f85c82ca7be78c88719188ba6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24a5334058de3376d65e897412c4f4f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d24cf3e37ec602dec09b276fca8074b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ef487b3a48ffd4fd7e84b59e49a1cf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2623d566feba6d27ea8be1a70c145466 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfa6c19fadf69a0179033348305315e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faa3c56800bbe7e6876801e5c5f7d2c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a24fd675a14d28588a2bd85a259f1cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b3c838bbdc545596552f3cfd8ea635d |
| publicationDate | 2001-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-335598-A |
| titleOfInvention | 1,2,4-oxadiazoles, processes for their preparation and their use for treating neurogenerative disorders |
| abstract | Oxadiazole derivatives of the general formula (I) for use in the treatment of neurodegenerative disorders and cerebral ischemia. Wherein; X and Y denote oxygen or nitrogen, wherein X and Y cannot both simultaneously be oxygen or nitrogen; Z denotes a group of Formula (II); S1 denotes the Formula (III); wherein V represents oxygen, sulphur or NR7 and B and D, which may be identical or different, denote a C1-4alkylene, C2-4alkenylene or C2-4alkynylene bridge, which may be substituted by =O, -OR7, phenyl or halogen; U represents C3-6cycloalkyl or phenyl group which may be substituted by C1-4alkyl, OR7, C6-10aryl or halogen; E denotes oxygen, sulphur or NR7 (with n,m=1,2 or 3 and n+m>2), and the group is optionally substituted by halogen, =O, OR7, or one or more C1-4alkyl groups; W may be a group of the Formula (IV) optionally substituted by halogen, =O, -OR7, -OCOR7, C1-4alkyl, C2-6alkenyl or C2-6alkynyl, wherein E denotes oxygen or NR7 and n, m, I may be 0, 1 or 2, or W is a C-linked 5- or 6-membered heterocyclic group which contains one or more heteroatoms from the group comprising nitrogen, oxygen or sulphur and may optionally be substituted by benzyl or C1-4alkyl; S2 denotes the Formula (V); S4 denotes the Formula (VI); Q denotes a fused-on, mono- or polyunsaturated 5- or 6-membered heterocyclic ring which may contain one or more heteroatoms from the group comprising oxygen, nitrogen or sulphur, and may optionally be substituted by OR7, NR5R6, halogen, CN, nitro, CF3, COOR7, C1-4alkyl, C2-4alkenyl or C2-4alkynyl; S5 denotes the Formula (VII); R1 denotes benzyl or phenyl, wherein the phenyl ring may optionally be mono- or polysubstituted by one or more of the following groups: fluorine, chlorine or bromine, C1-4alkyl, -CF3, -CR7=NOR7, -NMe2, Net2, -NO2 or -OR7; phenyl further substituted by -V-D-R4, a C- or N-linked 5 or 6-membered heterocycle which contains one or more heteroatoms from the group comprising nitrogen, oxygen or sulphur and may optionally be mono- or polysubstituted by benzyl, methyl, fluorine, chlorine, bromine or hydroxy; cyclopropyl, cyclopentyl or cyclohexyl, which is optionally substituted by =O or -OR7; norbornane, norbornene, dicyclopropylmethyl, adamantine or noradamantane, which are optionally substituted by methyl; Formula (VIII); -CH=CH-phenyl, wherein the phenyl ring may be substituted by methoxy or hydroxy; R2 denotes hydrogen, fluorine, chlorine or bromine, C1-4alkoxy, C1-4alkyl or hydroxy; R3 denotes hydrogen; R4 denotes hydroxy, CN or -NR5R6; an N-oxide of Formula (IX); R5 denotes hydrogen, C1-3alkyl, benzyl or phenyl; R6 denotes hydrogen, C1-3alkyl, benzyl or phenyl; or R5 and R6 together with the nitrogen atom form a saturated or unsaturated 5- or 6-membered ring, which may contain, as further heteroatoms, nitrogen, or oxygen, wherein the heterocycle may be mono- or polysubstituted by methyl; R7 denotes hydrogen, C1-4alkyl, a benzyl or phenyl group, wherein the phenyl ring is optionally mono- or polysubstituted by OH or OCH3; |
| priorityDate | 1996-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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