http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NZ-333996-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed3b1ee1e04d60cf850836bbdccd320b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-106 |
| filingDate | 1995-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4331ecbbc7f7aea2e9d0a3d977c201f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8321c5210fbddd2b91d2da162d15793 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_986bb33659e95c2336e1f07cc6d6990f |
| publicationDate | 2000-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NZ-333996-A |
| titleOfInvention | Method and vaccine containing enteric bacteria with antigenic properties |
| abstract | A method of producing an enteric bacterium having enhanced antigenic properties selected from: Campylobacter sp, Yersinia sp, Bacteroides sp, Klebiella sp, Enterobacter sp, Gastrospirillum sp, Salmonella sp, Shigella, sp Aeromonas, Vibrio sp Clostridium sp, Enterococcus sp and Eschericha coli Comprising growing a culture of enteric bacteria in vitro in a combination of conditions comprising; a) a divalent cation chelator selected from 1.0-25ìM of BAPTA/AM, 0.5-10ìM EGTA and 1.0-100ìM EGTA/AM; b) at a temperature between 30-42oC; c) in air or an microaerophillic condition, wherein the microaerophillic condition comprises i) 5-20% CO2 with 80-95% air ii) 5-10% O2 with 10-20% CO2 with about 70-85% N2 for a sufficient time so that the culture is in a growth phase at about early log phase, between early log phase and stationary phase, or at about stationary phase, wherein the enhanced antigenic property is a higher level of immunogenic antigenicity when compared to the antigenic property of bacteria from a culture of Helicobacter species in brain heart infusion broth supplemented with bovine calf serum. |
| priorityDate | 1994-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.