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filingDate 1997-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f89a7eb9d814097f01b6b05e9285240c
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publicationDate 2000-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NZ-333870-A
titleOfInvention 4-amino substituted chroman derivatives
abstract The chroman derivatives or their salts has the formula I wherein: R1 is H, halogen or optionally substituted alkyl, alkoxy or cycloalkyl, nitro, cyano, formyl, carboxyl, hydroxyl, formamido, cyanamide, amino, optionally substituted alkylamino or di-alkylamino, alkylcarbonylamino, alkylsulphonylamino, aminocarbonyl, alkylaminocarbonyl, di-alkylaminocarbonyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkylurea, alkylthiourea, optionally substituted aryl-alkylamino, di-(aralkyl)amino, arylcarbonylamino, aralkylcarbonylamino, arylsulphonylamino, aralkylsulphonylamino, aralkylaminocarbonyl, di-aralkylaminocarbonyl, arylcarbonyl, aralkylcarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, arylcarbonyloxy, aralkylcarbonyloxy, arylurea, aralkylurea, arylthiourea or aralkylthiourea; R3 and R4 are independently H, or optionally substituted alkyl or together with the carbon to which they are attached form a cycloalkyl group; R5 is OH, alkylcarbonyloxy or forms a bond with R6; R6 is H or forms a bond with R5; R7 and R8 are independently H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, -C(=Y')Z1R10 or -C(=Y')R10 or together form an optionally substituted 1,4-butylene or 1,5-pentylene or form -(CH2)l-X'-(CH2)p, -(CH2)q-Z1-C(=Y')- or -(CH2)q-c(=Y') or together with the nitrogen to which they are attached form optionally substituted pyrrolyl, pyrazolyl, imidazolyl, 1,2,3-triazolyl. 1,2,4-triazolyl or 1,2,3,4-tetrazolyl; n is 0 to 4; X is CO, CH2, SO2 or NR16; Y is NR17 when X is CO, CH2 or SO2 or CO when X is NR16; Z is absent or is CH2 or NR18; W is a group of formula II and the rest of the variables are as defined in the specification. A pharmaceutical composition thereof useful for treating cardiac insufficiency.
priorityDate 1996-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 47.