| abstract |
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolylphenyl derivatives of formula described that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives. In formula described, R and Z are as defined in the application where Z is the characterising feature. Z is selected from the group consisting of: a)tNR2-C(O)-Q-CH(R3)-NR4R5 b)tNR2AC(O)-A-NR3AR4A c)tC(O)-NR2BR3B d)tOCH2C(O)NR2CR3C e)tCH2CH2N(R2D)-C(O)R3D |