| abstract |
A particular class of metal complexes, specifically certain texaphyrin metal complexes shown in the formula above, which both hydrolyze and photocleave ribonucleic acid is described. Wherein, M is a divalent or trivalent metal cation; R1-R4, R7 and R8 are independently H, halide, OH, alkyl, alkenyl, alkynyl, aryl, haloalkyl, nitro, formyl, acyl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, hydroxyalkenyl, hydroxyalknyl, saccharide, carboxy, carboxyalkyl, carboxyamide, carboxyamidealkyl, amino, aminoalkyl, a site-directing molecule, a catalytic group, or a couple to a site-directing molecule or to a catalytic group; R6 and R9 are independently selected from R1-R4, R7 and R8, with the proviso that the halide is not iodide and the haloalkyl is other than iodoalkyl; R5 and R10-R12 are independently H, alkyl, alkenyl, alkynyl, aryl, hydroxyalkyl, oxyalkyl, oxyhydroxyalkyl, hydroxyalkenyl, hydroxyalknyl, carboxyalkyl, carboxyamide, carboxyamidealkyl, amino, aminoalkyl, or a couple to a saccharide, to a site-directing molecule or to a catalytic group; and Z is an integer value less than or equal to 5. The texaphyrin metal complex for each set of reactions has catalytic activity for phosphate ester hydrolysis and is photosensitive. The photocleavage reaction occurs between 650-900 nm of the spectral range. A complex having the advantage of multiple activities can result in lower treatment dosages and lower treatment costs. |